Brueckl, W. M. and Grombach, J. and Wein, A. and Ruckert, S. and Porzner, M. and Dietmaier, Wolfgang and Ruemmele, Petra and Croner, R. S. and Boxberger, F. and Kirchner, T. and Hohenberger, W. and Hahn, E. G. and Jung, A. (2005) Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal turnours displaying either microsatellite stability (MSS) or instability (MSI). CANCER LETTERS, 223 (1). pp. 137-142. ISSN 0304-3835, 1872-7980
Full text not available from this repository. (Request a copy)Abstract
Methylation of promoter regions and frameshift mutations in microsatellites of the coding sequence (CDs) of genes are frequently associated with loss of expression in microsatellite instable (MSI) colorectal carcinoma. In a panel of 40 MSI and 24 microsatellite stable (MSS) colorectal tumours as well as six cultured colorectal carcinoma cell lines hypermethylation of the TIMP3-promoter was found in 28% of MSI and 25% of MSS tumours, respectively. Additionally, three MSI tumours and one cell line displayed instability of a C-7-repeat located in the CDs of the TIMP-3 gene. TIMP-3 fulfils all important criteria for being a target gene in the mutator pathway. Thus, TIMP-3 might be a factor of general importance for colorectal carcinogenesis. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SORSBYS FUNDUS DYSTROPHY; CANCER; DEATH; METHYLATION; EXPRESSION; PHENOTYPE; PROTEIN; tissue inhibitor of matrix metalloproteinase-3 (TIMP-3); colorectal carcinoma; microsatellite instability (MSI); mismatch repair (MMR) deficiency; Sorsby fundus dystrophy (SFD) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 May 2021 11:45 |
| Last Modified: | 10 May 2021 11:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36031 |
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