Roesch, Alexander and Haegele, Till and Vogt, Thomas and Babilas, Philipp and Landthaler, Michael and Szeimies, Rolf-Markus (2005) Severe contact urticaria to guar gum included as gelling agent in a local anaesthetic. CONTACT DERMATITIS, 52 (6). pp. 307-308. ISSN 0105-1873, 1600-0536
Full text not available from this repository. (Request a copy)Abstract
We report the first case of a life-threatening immediate-type hypersensitivity caused by Dynexan(TM), a local anaesthetic gel. After mucosal application by his dentist, a 63-year-old man rapidly developed urticaria, dyspnea and, at last, he collapsed and remained unconscious for 2 hr despite emergency care. While the standard prick tests were negative to all local anaesthetics tested including lidocaine, a 1-fold positive reaction was detected to Meyprogat 60 (TM), an ingredient of Dynexan(TM). As the gelling agent Meyprogat 60(TM) represents a derivative of guar (synonymous guar gum, guaran, E-412), we subsequently tested different guar products derived from Cyamopsis tetragonoloba beans and, as control, the closely related locust bean gum E-410. In the prick-to-prick tests, the guar-derived food additive Provigel(TM) NAG 905 provoked a 1-fold positive reaction. Native guar beans pounded and resuspended in water showed a 2-fold positive reaction, whereas no reaction was found to derivatives of locust bean gum. Specific immunoglobulin E were negative in all cases. Despite the common use of guar as versatile food additive or gelling agent, this is the first case of a severe immediate-type hypersensitivity after mucosal contact.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OCCUPATIONAL ASTHMA; adverse drug reaction; contact urticaria; exposure analysis; guar gum |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 May 2021 11:59 |
| Last Modified: | 10 May 2021 11:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36034 |
Actions (login required)
 |
View Item |
