von Lukowicz, T. and Fischer, M. and Hense, H. W. and Doring, A. and Stritzke, J. and Riegger, Guenter and Schunkert, H and Luchner, Andreas (2005) BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy. EUROPEAN JOURNAL OF HEART FAILURE, 7 (4). pp. 525-531. ISSN 1388-9842, 1879-0844
Full text not available from this repository. (Request a copy)Abstract
BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi). BNP increased in subjects with diastolic dysfunction (mean 20.3 +/- 4.7 pg/ml vs. control 9.6 +/- 0.5 pg/ml, p < 0.001), but to a lesser extent than in subjects with LV hypertrophy (LVH, mean 37.3 +/- 49.1 pg/ml, p < 0.001 vs. control) or LVSD (mean 76.2 +/- 23.2 pg/ml, p < 0.001 vs. control). Individuals with sole diastolic abnormality displayed BNP concentrations at the control level (mean 9.7 +/- 1.7 pg/ml). In univariate analysis, age, BMI, systolic blood pressure, left atrial size, LV mass index, diastolic dysfunction and EF displayed a significant correlation with BNP (p < 0.001). However, LV mass index displaced diastolic dysfunction as a significant predictor of BNP in multivariate analysis. Upon ROC analysis, sensitivity and specificity for the detection of diastolic dysfunction by BNP were only 61% and 55%, respectively. Nevertheless, a normal BNP test virtually excluded the presence of diastolic dysfunction and concomitant LVH (NPV 99.9%). Increased BNP concentrations in subjects with diastolic dysfunction are strongly related to LVH. Population-wide screening for diastolic dysfunction with BNP cannot be recommended although a normal BNP test usually excludes diastolic dysfunction and LV hypertrophy. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BRAIN NATRIURETIC PEPTIDE; CONVERTING ENZYME-INHIBITOR; HEART-FAILURE; SYSTOLIC DYSFUNCTION; PLASMA BRAIN; ESSENTIAL-HYPERTENSION; EMERGENCY DIAGNOSIS; BODY-COMPOSITION; COMMUNITY; PREVALENCE; heart failure; diastolic dysfunction; BNP; LV hypertrophy; echocardiography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 May 2021 12:13 |
| Last Modified: | 10 May 2021 12:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36040 |
Actions (login required)
 |
View Item |
