Oesterreicher, Christoph H. and Datz, C. and Stickel, F. and Hellerbrand, Claus and Penz, M. and Hofer, H. and Wrba, F. and Penner, E. and Schuppan, D. and Ferenci, Peter (2005) Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis. JOURNAL OF HEPATOLOGY, 42 (6). pp. 914-919. ISSN 0168-8278, 1600-0641
Full text not available from this repository. (Request a copy)Abstract
Background/Aims: Hereditary hemochromatosis (HHC) is a disorder of iron metabolism with variable penetrance. Oxidative stress plays a central role in the progression to cirrhosis. Several enzymes involved in the production or degradation of reactive oxidants, like myeloperoxidase (MPO) and heme oxygenase (HO)-1 are influenced by promotor polymorphisms. This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)(n) on the evolution of cirrhosis in patients with HHC. Methods: One-hundred and fifty-eight C282Y homozygotes without cofactors for fibrosis progression (119 males; mean age: 51.0 +/- 13.3) were studied. All patients underwent liver biopsy. Hepatic iron content was measured by atom absorption spectrophotometry. MPO polymorphism was assessed by RFLP analysis; HO-1 microsatellite polymorphism by a laser-based semi-automated DNA sequencer. Results: The MPO genotypes GG, GA, and AA were found in 102 (64.6%), 45 and 11 patients, respectively. The GG-genotype was more common in patients with cirrhosis than in those without (78.7 vs. 55.7 %, P = 0.003). The distribution of HO-I genotypes was not different. Logistic regression analysis revealed MPO genotype-GG, serum ferritin, age and male sex as independent predictors for cirrhosis. Conclusions: MPO genotype GG is associated with cirrhosis in patients with hereditary hemochromatosis. (C) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OXYGENASE-1 GENE PROMOTER; CHRONIC HEPATITIS-C; STELLATE CELL ACTIVATION; HEME OXYGENASE-1; OXIDATIVE STRESS; MICROSATELLITE POLYMORPHISM; IMPLICATES MYELOPEROXIDASE; VIRUS-INFECTION; LIVER-DAMAGE; IRON; hereditary hemochromatosis; oxidative stress; liver fibrosis; host factors; genetic polymorphism; myeloperoxidase (MPO); heme oxygenase-1 (HO-1); reactive oxygen species (ROS); hepatic iron concentration (HIC) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2021 09:32 |
| Last Modified: | 11 May 2021 09:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36070 |
Actions (login required)
 |
View Item |
