Kunzelmann, Karl (2005) Ion channels and cancer. JOURNAL OF MEMBRANE BIOLOGY, 205 (3). pp. 159-173. ISSN 0022-2631, 1432-1424
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Membrane ion channels are essential for cell proliferation and appear to have a role in the development of cancer. This has initially been demonstrated for potassium channels and is meanwhile also suggested for other cation channels and Cl- channels. For some of these channels, like voltagegated ether a go-go and Ca2+-dependent potassium channels as well as calcium and chloride channels, a cell cycle-dependent function has been demonstrated. Along with other membrane conductances, these channels control the membrane voltage and Ca2+ signaling in proliferating cells. Homeostatic parameters, such as the intracellular ion concentration, cytosolic pH and cell volume, are also governed by the activity of ion channels. Thus it will be an essential task for future studies to unravel cell cycle-specific effects of ion channels and non-specific homeostatic functions. When studying the role of ion channels in cancer cells, it is indispensable to choose experimental conditions that come close to the in vivo situation. Thus, environmental parameters, such as low oxygen pressure, acidosis and exposure to serum proteins, have to be taken into account. In order to achieve clinical application, more studies on the original cancer tissue are required, and improved animal models. Finally, it will be essential to generate more potent and specific inhibitors of ion channels to overcome the shortcomings of some of the current approaches.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CA2+-ACTIVATED K+ CHANNELS; CYCLE-DEPENDENT EXPRESSION; REGULATED ANION CHANNELS; HUMAN PROSTATE-CANCER; APOPTOTIC VOLUME DECREASE; TUMOR-CELL PROLIFERATION; ACTIVATED CL-CURRENTS; GO POTASSIUM CHANNELS; INTERMEDIATE-CONDUCTANCE; CHLORIDE CHANNEL; cancer; ion channels; K+ channels; Cl- channels; proliferation; cell cycle; mitogens; oncogenic; apoptosis; growth |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann |
| Depositing User: | Petra Gürster |
| Date Deposited: | 12 Apr 2022 09:08 |
| Last Modified: | 12 Apr 2022 09:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36075 |
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