Moeglich, Andreas and Weinfurtner, Daniel and Gronwald, Wolfram and Maurer, Till and Kalbitzer, Hans Robert (2005) PERMOL: restraint-based protein homology modeling using DYANA or CNS. BIOINFORMATICS, 21 (9). pp. 2110-2111. ISSN 1367-4803, 1460-2059
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PERMOL is a new restraint-based program for homology modeling of proteins. Restraints are generated from the information contained in structures of homologous template proteins. Employing the restraints generated by PERMOL, three-dimensional structures are obtained using MD programs such as DYANA or CNS. In contrast to other programs PERMOL is mainly based on the use of dihedral angle information which is optimally suited to preserve the local secondary structure. The global arrangement of these elements is then facilitated by a small number of distance restraints. Using PERMOL homology, models of high quality are obtained. A key advantage of the proposed method is its flexibility, which allows the inclusion of data from other sources, such as experimental restraints and the use of modern molecular dynamics programs to calculate structures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTAINING PHOSPHOCARRIER PROTEIN; TORSION ANGLE DYNAMICS; PREDICTION; DOMAIN; SYSTEM; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2021 06:42 |
| Last Modified: | 14 May 2021 06:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36155 |
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