Ewing, Patricia and Wilke, A. and Eissner, Guenther and Holler, Ernst and Andreesen, Reinhard and Gerbitz, Armin (2005) Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis. ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 12 (3). pp. 113-119. ISSN 1062-3329,
Full text not available from this repository.Abstract
A common side effect of therapeutic use of ionizing irradiation is endothelial cell damage resulting in a variety of clinical complications. Thus, preservation of endothelial function after irradiation could potentially limit toxicity. Using the murine endothelioma cell line bEnd2 we show here that induction of heme oxygenase-1 (HO-1) by cobalt protoporphyrine IX (CoPP) inhibits irradiation-induced apoptosis. In contrast, HO-1 induction by tin protoporphyrine IX (SnPP), a HO-1 inhibitor, does not affect survival after irradiation. The protective effects of CoPP could be partially reversed by blockade of HO-1 function with SnPP after induction by CoPP. Vice versa, blockade of HO-1 function by SnPP was reversible using CoPP. Treatment with CoPP inhibited cytochrome c release induced by irradiation. These results demonstrate that HO-1 induction and activation prior to irradiation inhibits endothelial apoptosis and might be used for possible cell protection in vivo.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RADIATION-INDUCED APOPTOSIS; IONIZING-RADIATION; CARBON-MONOXIDE; INHIBITS APOPTOSIS; CYTOCHROME-C; BONE-MARROW; INJURY; INFLAMMATION; INDUCTION; PATHWAY; apoptosis; endothelial; heme oxygenase-1; irradiation; protoporphyrine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2021 06:55 |
| Last Modified: | 14 May 2021 06:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36164 |
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