Boeger, Carsten A. and Goetz, Angela K. and Krueger, Bernd and Hoesl, M. and Schmitz, Gerd and Riegger, Guenter A. J. and Kraemer, Bernhard K. (2005) Effect of genetic variation on therapy with angiotensin converting enzyme inhibitors or angiotensin receptor blockers in dialysis patients. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 10 (4). pp. 161-168. ISSN 0949-2321, 2047-783X
Full text not available from this repository. (Request a copy)Abstract
Introduction: The role of interaction of polymorphisms in the Renin-Angiotensin-System (RAS) with angiotensin converting enzyme (ACE) or angiotensin receptor (AGTR1) inhibitors (RAS inhibitors) is unknown, as is the role of such therapy in end stage renal disease (ESRD) patients. Methods: We enrolled all 445 prevalent patients with diabetic nephropathy receiving maintenance hemodialysis in 30 centers in Southern Germany, from August 1999 to January 2000 for prospective survival analysis until December 2003. Blood pressure and medication was recorded at inclusion. We determined survival specific for allelic variants of the ACE (insertion/deletion), Angiotensinogen (M235T) and AGTR1 (A1166C) genes. The effect of therapy with RAS inhibitors at study inclusion was determined for the allelic variants of each gene. The primary end point was all cause mortality (ACM). Results: For all polymorphisms, and for therapy with RAS inhibitors there was no significant effect on survival in the complete collective (n = 445), though there was an insignificant trend for improved survival in patients on AGTR1 antagonists. Increased ACM risk was associated with treatment with RAS inhibitors only in patients homozygous for the wild type AGTR1116A allele (HR 1.65, p=0.01). For all other polymorphisms, therapy with RAS inhibitors had no significant effect on ACM, irrespective of genotype. Similar results were obtained in patients with systolic ventricular dysfunction. Conclusion: Our data do not show a survival advantage for type 2 diabetes hemodialysis patients receiving RAS inhibiting therapy. In addition, our data indicate that allelic variation in RAS genes and pharmacogenetic interaction with RAS inhibition does not affect mortality, risk in diabetic hemodialysis patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-ARTERY-DISEASE; CONGESTIVE-HEART-FAILURE; STAGE RENAL-DISEASE; DELETION POLYMORPHISM; BLOOD-PRESSURE; PHARMACOGENETIC INTERACTIONS; MYOCARDIAL-INFARCTION; HEMODIALYSIS-PATIENTS; CARDIOVASCULAR RISK; OXIDATIVE STRESS; hypertension; dialysis; renin-angiotensin-system; genetics; diabetes mellitus; nephropharmacology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2021 05:08 |
| Last Modified: | 17 May 2021 05:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36250 |
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