Härle, P. and Bongartz, T. and Schoelmerich, Juergen and Mueller-Ladner, Ulf and Straub, Rainer H. (2005) Predictive and potentially predictive factors in early arthritis: a multidisciplinary approach. RHEUMATOLOGY, 44 (4). pp. 426-433. ISSN 1462-0324, 1462-0332
Full text not available from this repository. (Request a copy)Abstract
Objectives. Rheumatoid arthritis (RA) is characterized by variable degrees of joint inflammation, joint destruction, progressive disability and premature death. Destruction of joint cartilage and bone may occur early during disease, as was shown in longitudinal studies of RA, and there is increasing consent among rheumatologists that early diagnosis and early initiation of therapy with disease-modifying anti-rheumatic drugs (DMARDs) can limit the severity of RA. Unfortunately, the currently used diagnostic and predictive indicators (clinical, laboratory and radiological) are of limited value for making an early diagnosis and prognosis of the disease course at the individual level, thus reducing optimal benefit from present and emerging therapies. Therefore, this review focuses on the multidisciplinary aspects of neuroendocrine-immune changes in RA. Methods. A Medline search was performed using the search terms 'androgens', 'estrogens', 'sympathetic nervous system', 'sensory nervous system', 'prognosis', 'early rheumatoid arthritis', 'arthritis' and 'studies' in various combinations. For the tabular overview, we only listed clinical studies focusing on endocrine and neuronal aspects. Results. In addition to the currently used predictive indicators, there is an abundant body of literature describing changes of the neuronal, endocrine and immune parameters during inflammatory diseases. Unfortunately, no longitudinal studies concerning neuroendocrine aspects have been done up to now. Conclusion. Parameters of the neuroendocrine system should be included in anticipated longitudinal clinical studies to find their true predictive value in early RA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; AUTONOMIC NERVOUS HYPERREFLEXIA; DIAGNOSED RHEUMATOID-ARTHRITIS; CORTICOTROPIN-RELEASING FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TUMOR-NECROSIS-FACTOR; IN-VITRO; ANDROGEN SECRETION; ULCERATIVE-COLITIS; INTERLEUKIN-6 IL-6; immune system; endocrine system; nervous system; prognosis; early rheumatoid arthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Mar 2022 08:56 |
| Last Modified: | 16 Mar 2022 08:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36343 |
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