Lee, YJ and Hohoff, C and Domschke, K and Sand, P and Kuhlenbaumer, G and Schirmacher, A and Freitag, CM and Meyer, J and Stober, G and Franke, P and Nothen, MM and Fritze, J and Fimmers, R and Garritsen, HS and Stogbauer, F and Deckert, J (2005) Norepinephrine transporter (NET) promoter and 5 '-UTR polymorphisms: association analysis in panic disorder. NEUROSCIENCE LETTERS, 377 (1). pp. 40-43. ISSN 0304-3940, 1872-7972
Full text not available from this repository. (Request a copy)Abstract
Several biochemical and pharmacological studies suggest that the catecholaminergic system involving the norepinephrine transporter (NET) is relevant for the pathogenesis of panic disorder. Three single nucleotide polymorphisms in the promoter or untranslated 5' region of the NET gene were investigated by means of RFLP analysis in a sample of 115 German patients with panic disorder and 115 matched controls. Statistical analysis failed to show association with the overall diagnosis of panic disorder. In the subgroup of patients with panic disorder without agoraphobia, however, two polymorphisms were found to be associated with the disease (G/C (rs2397771): p < 0.05; T/C (rs2242446): p < 0.01). While our data do not support a major function of the NET gene in the development of panic disorder, it may play a role in the subgroup of panic disorder without agoraphobia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE; ANXIETY; LOCUS; IDENTIFICATION; CHROMOSOME-16; TRANSCRIPTION; EPIDEMIOLOGY; SEQUENCE; panic disorder; agoraphobia; NET; SLC6A2; promoter; SNP; association |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2021 10:35 |
| Last Modified: | 19 May 2021 12:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36357 |
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