Filament depolymerization by motor molecules

Klein, GA and Kruse, K and Cuniberti, G and Julicher, F (2005) Filament depolymerization by motor molecules. PHYSICAL REVIEW LETTERS, 94 (10): 108102. ISSN 0031-9007,

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Abstract

Motor proteins that specifically interact with the ends of cytoskeletal filaments can induce filament depolymerization. A phenomenological description of this process is presented. We show that under certain conditions motors dynamically accumulate at the filament ends. We compare simulations of two microscopic models to the phenomenological description. The depolymerization rate can exhibit maxima and dynamic instabilities as a function of the bulk motor density for processive depolymerization. We discuss our results in relation to experimental studies of Kin-13 family motor proteins.

Item Type: Article
Uncontrolled Keywords: KINESIN-RELATED PROTEIN; NUCLEATION; MECHANISM;
Subjects: 500 Science > 530 Physics
Divisions: Physics > Institute of Theroretical Physics > Alumni or Retired Professors > Group Gianaurelio Cuniberti
Depositing User: Dr. Gernot Deinzer
Date Deposited: 20 May 2021 13:09
Last Modified: 20 May 2021 13:09
URI: https://pred.uni-regensburg.de/id/eprint/36363

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