Hildebrandt, GC and Olkiewicz, KM and Choi, S and Corrion, LA and Clouthier, SG and Liu, C and Serody, JS and Cooke, KR (2005) Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation. BLOOD, 105 (6). pp. 2249-2257. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
Idiopathic pneumonia syndrome (IPS) is a major cause of mortality following allogeneic stem cell transplantation (allo-SCT). Clinical and experimental data support a role for conditioning-induced inflammation and alloreactive T-cell responses in IPS pathophysiology, but the mechanisms by which donor leukocytes are ultimately recruited to the lung are not fully understood. RANTES is a chemokine ligand that is up-regulated during inflammation and promotes the recruitment of T cells and macrophages to sites of tissue damage. Using a lethally irradiated murine SCT model (B6 -> B6D2F1), we evaluated the role of donor leukocyte-derived RANTES in the development of IPS. Pulmonary mRNA and protein levels of RANTES were significantly elevated in allo-SCT recipients compared to syngeneic controls and were associated with enhanced mRNA expression of CCR5 and CCR1 and with inflammatory cell infiltration into the lung. Allo-SCT with RANTES-/- donor cells significantly decreased IPS and improved survival. Combinations of allogeneic wild-type or RANTES-/- bone marrow with wild-type or RANTES-/- T cells demonstrated that the expression of RANTES by donor T cells was critical to the development of lung injury after SCT. These data reveal that donor T cells can help regulate leukocyte recruitment to the lung after allo-SCT and provide a possible mechanism through which inflammation engendered by SCT conditioning regimens is linked to allo-specific T-cell responses during the development of IPS. (c) 2005 by The American Society of Hematology.
| Item Type: | Article |
|---|---|
| Additional Information: | Prepublished online as Blood First Edition Paper, November 16, 2004; DOI 10.1182/blood-2004-08-3320. |
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; LUNG ALLOGRAFT-REJECTION; TOTAL-BODY IRRADIATION; SEVERE APLASTIC-ANEMIA; CHEMOKINE EXPRESSION; TNF-ALPHA; INTERSTITIAL PNEUMONITIS; EPITHELIAL-CELLS; IFN-GAMMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 May 2021 13:42 |
| Last Modified: | 20 May 2021 13:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36366 |
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