Ermann, J. and Hoffmann, Petra and Edinger, Matthias and Dutt, S. and Blankenberg, F. G. and Higgins, J. P. and Negrin, R. S. and Fathman, C. G. and Strober, Samuel (2005) Only the CD62L(+) subpopulation of CD4(+)CD25(+) regulatory T cells protects from lethal acute GVHD. BLOOD, 105 (5). pp. 2220-2226. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
CD4(+)CD25(+) regulatory T (Treg) cells are potent modulators of alloimmune responses. In murine models of allogeneic bone marrow transplantation, adoptive transfer of donor CD4(+)CD25(+) Treg cells protects recipient mice from lethal acute graft-versus-host disease (aGVHD) induced by donor CD4(+)CD25(-) T cells. Here we examined the differential effect of CD62L(+) and CD62L(-) subsets of CD4(+)CD25(+) Treg cells on aGVHD-related mortality. Both subpopulations showed the characteristic features of CD4+CD25+ Treg cells in vitro and did not induce aGVHD in vivo. However, in cotransfer with donor CD4(+)CD25(-) T cells, only the CD62L(+) subset of CD4(+)CD25(+) Treg cells prevented severe tissue damage to the colon and protected recipients from lethal aGVHD. Early after transplantation, a higher number of donor-type Treg cells accumulated in host mesenteric lymph node (LN) and spleen when CD4(+)CD25(+)CD62L(+) Treg cells were transferred compared with the CD62L(-) subset. Subsequently, CD4(+)CD25(+)CD62L(+) Treg cells showed a significantly higher capacity than their CD62L(-) counterpart to inhibit the expansion of donor CD4(+)CD25(-) T cells. The ability of Treg cells to efficiently enter the priming sites of pathogenic allo-reactive T cells appears to be a prerequisite for their protective function in aGVHD. (C) 2005 by The American Society of Hematology
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; L-SELECTIN; IN-VIVO; ANTIGEN; HOMEOSTASIS; ACTIVATION; FACILITATE; INFUSION; LEUKEMIA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 May 2021 10:05 |
| Last Modified: | 18 May 2021 10:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36390 |
Actions (login required)
 |
View Item |
