Engeli, S and Bohnke, J and Gorzelniak, K and Janke, J and Schling, P and Bader, M and Luft, FC and Sharma, AM (2005) Weight loss and the renin-angiotensin-aldosterone system. HYPERTENSION, 45 (3). pp. 356-362. ISSN 0194-911X,
Full text not available from this repository. (Request a copy)Abstract
The renin- angiotensin- aldosterone system has been causally implicated in obesity- associated hypertension. We studied the influence of obesity and weight reduction on the circulating and adipose tissue renin- angiotensin- aldosterone system in menopausal women. Blood samples were analyzed for angiotensinogen, renin, aldosterone, angiotensin-converting enzyme activity, and angiotensin II. In adipose tissue biopsy samples, we analyzed angiotensinogen, renin, renin- receptor, angiotensin- converting enzyme, and angiotensin II type- 1 receptor gene expression. Obese women ( n = 19) had higher circulating angiotensinogen, renin, aldosterone, and angiotensin- converting enzyme than lean women ( n = 19), and lower angiotensinogen gene expression in adipose tissue. Seventeen women successfully participated in a weight reduction protocol over 13 weeks to reduce daily caloric intake by 600 kcal. Body weight was reduced by - 5%, as were angiotensinogen levels by - 27%, renin by - 43%, aldosterone by - 31%, angiotensin- converting enzyme activity by - 12%, and angiotensinogen expression by - 20% in adipose tissue ( all P < 0.05). The plasma angiotensinogen decrease was highly correlated with the waist circumference decline ( r = 0.74; P < 0.001). Weight and renin- angiotensin- aldosterone system reductions were accompanied by a - 7- mm Hg reduced systolic ambulatory blood pressure. These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin- angiotensin- aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIASTOLIC BLOOD-PRESSURE; ADIPOSE-TISSUE; FAT DISTRIBUTION; OBESE-PATIENTS; INSULIN-RESISTANCE; M235T POLYMORPHISM; GENETIC-VARIATION; BODY-FAT; HYPERTENSION; REDUCTION; adipose tissue; aldosterone; angiotensinogen; hypertension; obesity; renin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 May 2021 14:10 |
| Last Modified: | 20 May 2021 14:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36418 |
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