Placzek, M. and Gaube, S. and Kerkmann, U. and Gilbertz, K. P. and Herzinger, T. and Haen, Ekkehard and Przybilla, B. (2005) Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 124 (2). pp. 304-307. ISSN 0022-202X, 1523-1747
Full text not available from this repository. (Request a copy)Abstract
DNA damage caused by ultraviolet (UV) irradiation is considered the main etiologic factor contributing to the development of skin cancer. Systemic or topical application of antioxidants has been suggested as a protective measure against UV-induced skin damage. We investigated the effect of long-term oral administration of a combination of the antioxidants ascorbic acid (vitamin C) and D-alpha-tocopherol (vitamin E) in human volunteers on UVB-induced epidermal damage. The intake of vitamins C and E for a period of 3 mo significantly reduced the sunburn reaction to UVB irradiation. Detection of thymine dimers in the skin using a specific antibody revealed a significant increase of this type of DNA damage following UVB exposure. After 3 mo of antioxidant administration, significantly less thymine dimers were induced by the UVB challenge, suggesting that antioxidant treatment protected against DNA damage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORAL VITAMIN-E; HAIRLESS MICE; TOPICAL APPLICATION; OXIDATIVE STRESS; INDUCED ERYTHEMA; SKIN DAMAGE; RADIATION; INHIBITION; LIGHT; SUNBURN; human skin; ultraviolet radiation; antioxidants; DNA damage; thymine dimers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 May 2021 07:11 |
| Last Modified: | 31 May 2021 07:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36531 |
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