Tandon, V. K. and Rai, Sanjay (2005) 2,3,4,5-Tetrahydro-1-benzoxepines a novel class of anti-implantation agents. LETTERS IN DRUG DESIGN & DISCOVERY, 2 (1). pp. 36-39. ISSN 1570-1808, 1875-628X
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5-Substituted 2,3,4,5-Tetrahydro-1-benzoxepine derivatives have been synthesized as novel anti-implantation agents. The synthesized compounds were evaluated for their anti-implantation activity in mature female Sprague-Dawley rats. The most active compounds in this series 10d and 11d, are 67% active in preventing implantation in rats at 10 mgkg(-1) dose. We also found that the other compounds of the series have lesser anti-implantation activity compared to the most potent anti-implantation drug Centchroman 5.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIESTROGENS; benzoxepines; anti-implantation; anti-fertility; non-steroidal; anti-estrogens |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 May 2021 06:49 |
| Last Modified: | 31 May 2021 06:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36537 |
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