Deml, Ludwig and Speth, Cornelia and Dierich, Manfred P. and Wolf, Hans and Wagner, Ralf (2005) Recombinant HIV-1 Pr55(gag) virus-like particles: potent stimulators of innate and acquired immune responses. MOLECULAR IMMUNOLOGY, 42 (2). pp. 259-277. ISSN 0161-5890
Full text not available from this repository. (Request a copy)Abstract
Several previous reports have clearly demonstrated the strong effectiveness of human immunodeficiency virus (HIV) Gag polyprotein-based virus-like particles (VLP) to stimulate humoral and cellular immune responses in complete absence of additional adjuvants. Yet, the mechanisms underlying the strong immunogenicity of these particulate antigens are still not very clear. However, current reports strongly indicate that these VLP act as "danger signals" to trigger the innate immune system and possess potent adjuvant activity to enhance the immunogenicity of per se only weakly immunogenic peptides and proteins. Here, we review the current understanding of how various particle-associated substances and other impurities may contribute to the observed immune-activating properties of these complex immunogens. (C) 2004 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOTOXIC T-LYMPHOCYTE; BACULOVIRUS-INFECTED CELLS; B SURFACE-ANTIGEN; CLASS-I MOLECULES; DROSOPHILA SCHNEIDER-2 CELLS; RETROVIRUS-LIKE PARTICLES; PARVOVIRUS-LIKE PARTICLES; ROUS-SARCOMA-VIRUS; GAG-ENV PARTICLES; HIV; gag; virus-like particles; innate immunity; adaptive immunity; vaccine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 22 Mar 2022 07:58 |
| Last Modified: | 22 Mar 2022 07:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36539 |
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