Schäffler, Andreas and Schölmerich, Jürgen and Büchler, Christa (2005) Mechanisms of disease: adipocytokines and visceral adipose tissue-emerging role in intestinal and mesenteric diseases. NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 2 (2). pp. 103-111. ISSN 1743-4378
Full text not available from this repository. (Request a copy)Abstract
Adipose tissue has long been regarded as a passive type of connective tissue that stores energy as triglycerides and releases energy as free fatty acids, however, this point of view has now changed. The wide variety of products expressed and secreted by adipose tissue, such as adiponectin, leptin, and resistin, mean that the total adipose tissue mass can be defined as a real endocrine organ. The anatomic, metabolic and biochemical characteristics of visceral adipose tissue make it interesting in the context of intestinal and mesenteric diseases. These characteristics include increased lipolysis, venous drainage via the portal vein and local glucocorticoid excess owing to the specific expression of 11-β-hydroxysteroid-dehydrogenase type 1. In this review, the role of the visceral adipose tissue and its secretory products in intestinal and mesenteric diseases is systematically reviewed, with special focus on 'creeping fat' in Crohn's disease and mesenteric panniculitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; INFLAMMATORY-BOWEL-DISEASE; ACTIVATED RECEPTOR-GAMMA; CROHNS-DISEASE; INSULIN-RESISTANCE; SCLEROSING MESENTERITIS; FACTOR-ALPHA; PPAR-GAMMA; OBESITY; FAT; adipocytolkines; creeping fat; Crohn's disease; mesenteric panniculitis; visceral adipose tissue |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 22 Mar 2022 08:05 |
| Last Modified: | 22 Mar 2022 08:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36541 |
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