Mack, Matthias and Schneider, M. A. and Moll, Cordula and Cihak, J. and Bruhl, H. and Ellwart, J. W. and Hogarth, M. P. and Stangassinger, M. and Schlondorff, D. (2005) Identification of antigen-capturing cells as basophils. JOURNAL OF IMMUNOLOGY, 174 (2). pp. 735-741. ISSN 0022-1767, 1550-6606
Full text not available from this repository. (Request a copy)Abstract
Binding of intact Ag is a hallmark of Ag-specific B cells. Apart from B cells.. a small number of non-B cells can bind Ag with comparable efficacy as B cells and are found in the peripheral blood, spleen, and bone marrow of mice. This population has been observed for a long time and recently named "Ag-capturing cells." Their identity remained enigmatic. In this study, we show that these cells are basophilic granulocytes. Their ability to capture Ags is dependent on surface IgE receptors and on Ag-specific plasma IgE molecules appearing after immunization. Several surface markers including surface bound IgE, IL-3R. CD45, CD16/ 32, and the chemokine receptor CCR2 were used to clearly identify these cells. Cross-linkage of surface Igs results in the release of large amounts of IL-4 and IL-6. The data identify basophils as Ag-capturing cells and support the concept of basophils as important regulators of humoral immune responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN IGE SYNTHESIS; MEMORY B-CELLS; MAST-CELLS; CHEMOKINE RECEPTORS; DENDRITIC CELLS; MESSENGER-RNA; T-CELLS; EXPRESSION; MOUSE; RESPONSES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 May 2021 09:14 |
| Last Modified: | 31 May 2021 09:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36590 |
Actions (login required)
 |
View Item |
