Johann, Monika and Putzhammer, Albert and Eichhammer, Peter and Wodarz, Norbert (2005) Association of the-141C del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 132B (1). pp. 46-49. ISSN 1552-4841,
Full text not available from this repository. (Request a copy)Abstract
Several lines of evidence indicate an involvement of the dopaminergic system in alcoholism, withdrawal, suicidality, and attention-deficit hyperactivity disorder (ADHD). The functionally relevant -141C Ins/Del polymorphism. located upstream to exon 1 in the 5'-region of the dopamine D2 receptor (DRD2) gene might be an interesting candidate gene. We investigated a sample of 1,126 well-characterized, primary chronic alcoholics of German descent according to a phenotype-genotype strategy, i.e., alcoholics suffering from severe withdrawal complications such as seizure or delirium, family history positive (FH+) alcoholics, alcoholics with an antisocial personality disorder (ASPD), alcoholics with an ADHD, and type I or type 2 alcoholics according to Cloninger's typology. Compared to the control subjects, there was a significant excess of the -141C Del allele in alcoholics with a paternal and grand-paternal history of alcoholism and in alcoholic subgroups with suicidality or without a history of withdrawal symptoms. There were no significant differences in allele frequency between the entire group or subgroups of alcoholics and healthy controls. Therefore, the -141C Del variant of the DRD2 might be a protective factor against the development of withdrawal symptoms. However, it might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grand-paternal history of alcoholism and it might contribute to the substantially higher likelihood of suicide in alcoholics. (C) 2004 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NUCLEUS-ACCUMBENS; PROMOTER REGION; SEROTONIN TRANSPORTER; DEPENDENT PATIENTS; -141C INS/DEL; GENE; POLYMORPHISMS; DENSITY; REWARD; SCHIZOPHRENIA; alcoholism; dopamine D2 receptor gene (DRD2); -141C Ins/Del polymorphism; phenotype-genotype strategy; cloninger type 1/2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 May 2021 13:59 |
| Last Modified: | 31 May 2021 13:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36600 |
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