Friedel, S. and Horro, F. F. and Wermter, A. K. and Geller, F. and Dempfle, A. and Reichwald, K. and Smidt, J. and Bronner, G. and Konrad, K. and Herpetz-Dahlmann, B. and Warnke, A. and Hemminger, U. and Linder, M. and Kiefl, H. and Goldschmidt, H. P. and Siegfried, W. and Remschmidt, H. and Hinney, A. and Hebebrand, J. (2005) Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 132B (1). pp. 96-99. ISSN 1552-4841, 1552-485X
Full text not available from this repository. (Request a copy)Abstract
Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous Bdnf knockout mice (Bdnf(+/-)) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, dose-dependent appetite suppression and weight loss in rats. We searched for the role of BDNF variants in obesity, eating disorders, and attention-deficit/hyperactivity disorder (ADHD). A mutation screen (SSCP and DHPLC) of the translated region of BDNF in 183 extremely obese children and adolescents and 187 underweight students was performed. Additionally, we genotyped two common polymorphisms (rs6265: p.V66M; c.-46C > T) in 118 patients with anorexia nervosa, 80 patients with bulimia nervosa, 88 patients with ADHD, and 96 normal weight controls. Three rare variants (c.5C > T: p.T2I; c.273G > A; c.* 137A > G) and the known polymorphism (p.V66M) were identified. A role of the 12 allele in the etiology of obesity cannot be excluded. We found no association between p.V66M or the additionally genotyped variant c.-46C > T and obesity, ADHD or eating disorders. This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience. wiley.com/jpages/0148-7299:1/suppmat/index.html. (C) 2004 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SINGLE NUCLEOTIDE POLYMORPHISMS; MELANOCORTIN-4 RECEPTOR GENE; ANOREXIA-NERVOSA; WEIGHT-LOSS; MICE; HYPERPHAGIA; DISEASE; ONSET; weight regulation; BMI; anorexia nervosa; bulimia nervosa |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 May 2021 14:14 |
| Last Modified: | 31 May 2021 14:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36601 |
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