Aune, Dagfinn and Leitzmann, Michael and Vatten, Lars Johan (2016) Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, 13 (7). pp. 788-795. ISSN 1543-3080, 1543-5474
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Background: Physical activity has been hypothesized to reduce the risk of gallbladder disease (gallstones, cholecystitis, cholecystectomy); however, results from epidemiological studies have not always shown statistically significant associations. We conducted a systematic review and meta-analysis to clarify the presence and strength of an association between physical activity and gallbladder disease risk. Methods: PubMed and Embase databases were searched for studies of physical activity and gallbladder disease up to 9th of January 2015: Prospective studies reporting relative risk (RR) estimates and 95% confidence intervals (CIs) of gallbladder disease associated with physical activity were included. Summary RRs were estimated using a random effects model. Results: Eight studies including 6958 cases and 218,204 participants were included. The summary RR for the highest versus the lowest level of physical activity was 0.75 (95% CI: 0.69-0.81, n = 8) and there was no evidence of heterogeneity, I-2 = 0%). In the dose-response analysis the summary relative risk per 20 MET-hours of activity was 0.85 (95% CI: 0.80-0.90, I-2 = 0%, n = 2) for leisure-time physical activity, 0.83 (95% CI: 0.76-0.90, I-2 = 0%, n = 2) for vigorous physical activity, and 0.86 (95% CI: 0.76-0.98, I-2 = 0%, n = 2) for nonvigorous physical activity. Conclusion: Our analysis confirms a protective effect of physical activity on risk of gallbladder disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; DOSE-RESPONSE DATA; GALLSTONE DISEASE; INSULIN-RESISTANCE; SYMPTOMATIC GALLSTONES; LIFE-STYLE; WOMEN; MEN; EPIDEMIOLOGY; OBESITY; exercise; gallstones |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Aug 2020 08:29 |
| Last Modified: | 28 Aug 2020 08:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3662 |
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