Bongartz, Tim and Haerle, Peter and Friedrich, S. and Karrer, Sigrid and Vogt, T. and Seitz, A. and Muller-Ladner, Ulf (2005) Successful treatment of psoriatic onycho-pachydermo periostitis (POPP) with adalimumab. ARTHRITIS AND RHEUMATISM, 52 (1). pp. 280-282. ISSN 0004-3591,
Full text not available from this repository. (Request a copy)Abstract
Psoriatic onycho-pachydermo periostitis (POPP) is recognized as a rare subset of psoriatic arthritis, characterized by psoriatic onychodystrophy, connective tissue thickening above the distal phalanx, and a periosteal reaction. Therapy for this rare disease is based on treatments used for psoriatic arthritis, but traditional disease-modifying antirheumatic drugs, such as sulfasalazine and methotrexate, have shown inconsistent and unsatisfactory results. We report herein a successful therapeutic approach for POPP using the fully human anti-tumor necrosis factor (TNF) antibody adalimumab in a 42-year-old male patient. After 4 months of anti-TNF treatment, a remarkable normalization of the clinical appearance was achieved and magnetic resonance imaging showed complete resolution of the initial inflammatory lesions. Therefore, we consider a TNF-blocking strategy as promising for treatment of POPP.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTHRITIS; ETANERCEPT; TRIAL; TOE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Jun 2021 14:57 |
| Last Modified: | 01 Jun 2021 14:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36622 |
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