Koch, H. J. and Haas, S. and Jurgens, T. (2005) On the physiological relevance of muscarinic acetylcholine receptors in Alzheimer's disease. CURRENT MEDICINAL CHEMISTRY, 12 (24). pp. 2915-2921. ISSN 0929-8673, 1875-533X
Full text not available from this repository. (Request a copy)Abstract
The loss of cholinergic neurons, particularly in the forebrain, plays an important role in the pathophysiology of Alzheimer's disease (DAT). This concept has lead to the effective treatment of DAT by means of acetylcholine (Ach) esterase inhibitors. G-protein-coupled muscarinic acetylcholine receptors (mAchR) are classified in 5 subtypes, the M1 receptor stimulation and M2 inhibition being especially associated with cognitive skills. Modified cerebral muscarinic receptor profiles in patients with Alzheimer's disease in addition to loss of Ach releasing neurons help us to understand the pathophysiology of dementia and offer potential therapeutic approaches. Specific agonists and antagonists of muscarinic receptors are discussed as possible treatment options in DAT. Experimental results postulate a positive long lasting modulation of the pathological neuronal protein pattern in addition to their cholinomimetic effect.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AMYLOID PRECURSOR PROTEIN; NITRIC-OXIDE SYNTHASE; SIGNAL-TRANSDUCTION; TEMPORAL CORTEX; HUMAN BRAIN; AGONISTS; THERAPIES; BINDING; SYSTEM; ACTIVATION; muscarinic receptors; dementia; agonist; antagonist |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Mar 2022 06:34 |
| Last Modified: | 17 Mar 2022 06:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36673 |
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