Pongratz, Georg and Haerle, Peter and Schnellinger, Georg and Janele, David and Schoelmerich, Juergen and Straub, Rainer H. (2005) Norepinephrine in mice inhibits secretion of splenic IL-6 during the dark period but stimulates its secretion in the light period - possible role of the corticosterone tone. JOURNAL OF NEUROIMMUNOLOGY, 158 (1-2). pp. 120-127. ISSN 0165-5728, 1872-8421
Full text not available from this repository. (Request a copy)Abstract
In early morning hours, a rise of serum cytokines such as IL-6 was described. This study aimed to find reasons for this phenomenon focussing on NE and corticosterone. Mouse spleen slices were electrically stimulated (ES) in a microsuperfusion chamber in order to release endogenous NE. ES inhibited IL-6 secretion when animals were sacrificed at 03:00 and 06:00 (both p < 0.001) but it increased its secretion from spleen slice removed at 09:00 (p = 0.026). Prior administration of corticosterone or the glucocorticoid antagonist RU486 abrogated these ES effects. Endogenous NE via alpha- and beta-adrenoceptors mediated this time-dependent differential effects. This study demonstrates that cooperation of endogenous NE and corticosterone are involved in a time-dependent fall or rise of splenic IL-6 secretion. (C) 2004 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; TUMOR-NECROSIS-FACTOR; GLUCOCORTICOID-RECEPTOR; INTERLEUKIN-6 SECRETION; PLASMA INTERLEUKIN-6; CIRCADIAN-RHYTHMS; RHEUMATOID-ARTHRITIS; ADRENERGIC-RECEPTORS; BIOLOGICAL CLOCK; EPITHELIAL-CELLS; IL-6; spleen; daytime-dependent IL-6 release; corticosterone; norepinephrine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jun 2021 12:43 |
| Last Modified: | 07 Jun 2021 12:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36743 |
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