Schleyer, V. and Landthaler, Michael and Szeimies, Rolf-Markus (2005) Novel pharmacological approaches in the treatment of psoriasis. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 19 (1). pp. 1-20. ISSN 0926-9959, 1468-3083
Full text not available from this repository. (Request a copy)Abstract
Progress in the understanding of psoriasis as a T-cell mediated inflammatory disease has led to the development of new immunomodulatory therapies. Currently the main focus is on the so-called biologics (or biological agents), including fusion proteins, monoclonal antibodies, cytokines and selective receptors. They mainly target single steps in the complex cascade of humoral and cellular inflammatory immunomechanisms that finally lead to the accelerated growth of epidermal and vascular cells in the psoriatic lesions. The most promising and advanced biological agents are discussed along with their influence on the critical pathophysiological steps in psoriasis, including depletion of T cells, blockade of initial T-cell activation and T-cell receptor (TCR) stimulation, blockade of costimulatory signals and T-cell proliferative signals as well as restoration of the T helper type 1 (Th1)/Th2 balance by diminishing type I cytokines and administration of type 2 cytokines. In addition to the biological agents, further development of 'classical' dermatological therapies, such as retinoids, or the discovery of new indications for non-dermatological agents contribute to the novel pharmacological approaches in the treatment of psoriasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; TAZAROTENE 0.1-PERCENT GEL; CHRONIC PLAQUE PSORIASIS; GENERALIZED PUSTULAR PSORIASIS; MONOCLONAL-ANTIBODY TREATMENT; KILLED MYCOBACTERIUM-VACCAE; BONE-MARROW TRANSPLANTATION; RENAL-ALLOGRAFT RECIPIENTS; TACROLIMUS FK506 THERAPY; PPAR-GAMMA AGONISTS; biologics; immunotherapy; psoriasis; T cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Mar 2022 07:29 |
| Last Modified: | 03 Mar 2022 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36753 |
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