Zent, Olaf and Plentz, Annelie and Schwarz, Tino F. and Fruhwein, Nikolaus and Kuhr, Hans B. and Broeker, Michael and Banzhoff, Angelika and Jilg, Wolfgang (2004) TBE booster immunization according to the rapid immunization schedule: are 3-year booster intervals really necessary? VACCINE, 23 (3). pp. 312-315. ISSN 0264-410X,
Full text not available from this repository. (Request a copy)Abstract
In order to evaluate the need for further booster immunizations, 222 subjects aged 20-52 years, who had received the first booster dose with a new tick-borne encephalitis (TBE) vaccine in a preceding study, were invited for a serological follow-up. A total of 191 and 182 adult subjects were analyzed for the persistence of neutralizing TBE antibodies at I and 2 years following the first booster immunization, respectively. Both serological follow-ups revealed high levels of neutralizing TBE antibodies in more than 99% of subjects. Although an expected decline of the respective geometric mean titers (GMTs) was noted after booster immunization, the titers were still far above the values noted after primary immunization at the 2-year follow-up. The kinetic curve clearly indicates a longer persistence of neutralizing TBE antibodies than currently expected. To conclude, these results suggest that the administration of a further booster dose 3 years after the first one (according to current recommendations) does not seem to be necessary in this study population. (C) 2004 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TICK-BORNE ENCEPHALITIS; VACCINATION; IMMUNITY; ADULTS; tick-borne encephalitis; immunogenicity; safety; vaccine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jun 2021 09:28 |
| Last Modified: | 21 Jun 2021 09:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36873 |
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