Stroebel, Philipp and Rosenwald, Andreas and Beyersdorf, Niklas and Kerkau, Thomas and Elert, Olaf and Murumagi, Astrid and Sillanpaa, Niko and Peterson, Pärt and Hummel, Vera and Rieckmann, Peter and Burek, Christof and Schalke, Berthold and Nix, Wilfred and Kiefer, Reinhard and Mueller-Hermelink, Hans Konrad and Marx, Alexander (2004) Selective loss of regulatory T cells in thymomas. ANNALS OF NEUROLOGY, 56 (6). pp. 901-904. ISSN 0364-5134,
Full text not available from this repository. (Request a copy)Abstract
Myasthenia gravis (MG) is the prime autoimmune manifestation of thymomas. We investigated the generation of T cells with a regulatory phenotype (T-R) in thymomas with and without associated MG. In patients with MG(+) thymomas, maturation and export of T-R cells but not of other T-cell subsets was significantly reduced. We conclude that imbalance between effector and regulatory T cells in thymomas may be involved in modulation of onset and/or severity of MG.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNOLOGICAL SELF-TOLERANCE; MYASTHENIA-GRAVIS; EXPRESSION; GENERATION; EPITHELIUM; THYMUS; CD4(+); MATURE; BETA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jun 2021 09:47 |
| Last Modified: | 21 Jun 2021 09:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36877 |
Actions (login required)
 |
View Item |
