Dickinson, Anne M. and Middleton, Peter G. and Rocha, Vanderson and Gluckman, Eliane and Holler, Ernst (2004) Genetic polymorphisms predicting the outcome of bone marrow transplants. BRITISH JOURNAL OF HAEMATOLOGY, 127 (5). pp. 479-490. ISSN 0007-1048
Full text not available from this repository. (Request a copy)Abstract
Analysis of non-histocompatibility leucocyte antigen (HLA) functional genomics, together with conventional risk factors in haematopoietic stem cell transplantation (HSCT) can lead to predicting outcome in HLA-matched sibling transplant recipients. Polymorphisms of cytokine genes including tumour necrosis factor alpha, interleukin-10, interferon gamma and interleukin (IL)-6, associate with more severe acute graft-versus-host disease (aGvHD). Donor genotype for IL-1 receptor antagonist (IL-1Ra) has been associated with reduced aGvHD severity. Other genotypes (patient IL-1Ra, IL-6 and donor IL-1alpha) have been associated with chronic GvHD, or overall survival (Vitamin D receptor and oestrogen receptor). Polymorphisms within genes associated with host defence/inflammatory responses (mannose binding lectin genes, myeloperoxidase genes and the FCgamma receptors) have been associated with infections. Polymorphisms of pharmacogenes, such as methylenetetrahydrofolate-reductase, have been associated with aGvHD and other post-transplant complications. The NOD2 gene polymorphism, associated with Crohn's disease, has been shown to be associated with risk of gut GvHD. The majority of the studies have been carried out in single centre HLA-matched sibling cohorts and in relatively few matched unrelated donor transplants. This review gives an overall perspective of the current field of non-HLA genetics with regard to HSCT outcome, clinical relevance and potential application of the results to clinical management of HSCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; MINOR HISTOCOMPATIBILITY ANTIGENS; NECROSIS-FACTOR-ALPHA; T-CELLS; RHEUMATOID-ARTHRITIS; RELAPSED LEUKEMIA; FEMALE DONORS; ACUTE GVHD; TNF-ALPHA; haematopoietic stem cell transplants; gene polymorphisms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Feb 2022 07:26 |
| Last Modified: | 02 Feb 2022 07:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36886 |
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