Decressac, Sonia and Franco, Michel and Bendahhou, Said and Warth, Richard and Knauer, Sebastian and Barhanin, Jacques and Lazdunski, Michel and Lesage, Florian (2004) ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO REPORTS, 5 (12). pp. 1171-1175. ISSN 1469-221X, 1469-3178
Full text not available from this repository. (Request a copy)Abstract
TWIK1 belongs to a family of K+ channels involved in neuronal excitability and cell volume regulation. Its tissue distribution suggests a role in epithelial potassium transport. Here we show that TWIK1 is expressed in a subapical compartment in renal proximal tubules and in polarized MDCK cells. In nonpolarized cells, this compartment corresponds to pericentriolar recycling endosomes. We identified EFA6, an exchange factor for the small G protein ADP-ribosylation factor 6 (ARF6), as a protein binding to TWIK1. EFA6 interacts with TWIK1 only when it is bound to ARF6. Because ARF6 modulates endocytosis at the apical surface of epithelial cells, the ARF6/EFA6/TWIK1 association is probably important for channel internalization and recycling.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANINE KIDNEY-CELLS; POTASSIUM CHANNELS; ACTIN CYTOSKELETON; PLASMA-MEMBRANE; DOMAIN; PH; IDENTIFICATION; ENDOCYTOSIS; RECEPTORS; TUBULES; ion channel; small G protein; trafficking; recycling endosomes; apical compartment |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Richard Warth |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jun 2021 10:23 |
| Last Modified: | 21 Jun 2021 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36891 |
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