Driever, Pablo Hernaiz and Wagner, S. and Hofstadter, F. and Wolff, J. E. A. (2004) Valproic acid induces differentiation of a supratentorial primitive neuroectodermal tumor. PEDIATRIC HEMATOLOGY AND ONCOLOGY, 21 (8). pp. 743-751. ISSN 0888-0018, 1521-0669
Full text not available from this repository. (Request a copy)Abstract
In preclinical models the antiepileptic drug valproic acid induces differentiation of neoplastic cells, representing an evolving anticancer approach that takes into account that malignant cells resemble immature progenitor cells capable of terminal differentiation. The authors report on a child suffering from a relapsing supratentorial primitive neuroectodermal tumor that received valproic acid for epilepsy treatment over 7 months before the relapse. In contrast to the initial tumor, the relapsing tumor showed glial differentiation and low proliferation index. This is the first report of a relapsed supratentorial primitive neuroectodermal tumor that shows histologically confirmed signs of tumor cell differentiation induction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN NEUROBLASTOMA-CELLS; TRANS-RETINOIC ACID; MALIGNANT GLIOMA; PHASE-II; SODIUM VALPROATE; BRAIN-TUMORS; IN-VIVO; RECURRENT; CHILDREN; GLIOBLASTOMAS; differentiation induction; glial maturation; supratentorial primitive neuroectodermal tumor; valproic acid |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jun 2021 12:32 |
| Last Modified: | 21 Jun 2021 12:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36929 |
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