Kuphal, Silke and Poser, Ina and Jobin, C. and Hellerbrand, Claus and Bosserhoff, Anja Katrin (2004) Loss of E-cadherin leads to upregulation of NF kappa B activity in malignant melanoma. ONCOGENE, 23 (52). pp. 8509-8519. ISSN 0950-9232, 1476-5594
Full text not available from this repository. (Request a copy)Abstract
Malignant transformation of melanocytes frequently coincides with loss of E-cadherin expression. Here, we show that loss of E-cadherin leads to induction of nuclear factor kappa B (NFkappaB) activity in melanoma cell lines. Melanoma cells show constitutively active NFkappaB, whereas no activity is found in primary melanocytes. After reexpression of E-cadherin in melanoma cells, strong downregulation of NFkappaB activity was found. Consistently, NFkappaB activity was induced in primary human melanocytes after inhibition of E-cadherin activity by functionally blocking anti-E-cadherin antibodies. Interestingly, reexpression of E-cadherin-blocked p38 MAPK activity and the p38 MAPK inhibitors SB203580 and SB202190 almost completely prevented NFkappaB activation in melanoma cells. Furthermore, cytoplasmatic beta-catenin induced p38 and NFkappaB activation in malignant melanoma. To our knowledge, this is the first report suggesting a correlation between E-cadherin and NFkappaB activity in melanocytes and melanoma cells. In summary, we conclude that loss of E-cadherin and cytoplasmatic beta-catenin induces p38-mediated NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACTIVATED PROTEIN-KINASE; TUMOR-NECROSIS-FACTOR; LOBULAR BREAST CANCERS; CELL-CELL-ADHESION; BETA-CATENIN; EXPRESSION; P38; PATHWAY; GROWTH; GENE; melanoma; E-cadherin; p-p38; NF kappa B |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jun 2021 13:14 |
| Last Modified: | 21 Jun 2021 13:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36976 |
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