Pertz, Heinz H. and Elz, Sigurd and Schunack, Walter (2004) Structure-activity relationships of histamine H-1-receptor agonists. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 4 (9). pp. 935-940. ISSN 1389-5575
Full text not available from this repository. (Request a copy)Abstract
Significant progress in the development of potent and selective histamine H-1-receptor agonists has been achieved since 1990. Optimisation of the class of 2-phenylhistamines has furnished 2-[3(trifluoromethyl)phenyl]histamine and its N-alpha-methyl derivative. The discovery of histaprodifen (2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethanamine) and the novel lead compound suprahistaprodifen (N-alpha-2-[(1H-imidazol-4-yl)ethyl]histaprodifen) represents additional milestones in the H-1-receptor agonist field.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | H-1 RECEPTOR AGONISTS; IN-VITRO EVALUATION; G-PROTEIN; 2-SUBSTITUTED HISTAMINE; HISTAPRODIFEN ANALOGS; ANESTHETIZED RAT; POTENT; DERIVATIVES; PHARMACOLOGY; LIGANDS; histaprodifen; suprahistaprodifen; H-1-receptor agonist; partial agonist; guinea-pig ileum; guinea-pig aorta; guinea-pig trachea; rat aorta |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Feb 2022 06:22 |
| Last Modified: | 02 Feb 2022 06:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37010 |
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