Ibach, Bernd and Wittmann, Markus and Pfannenschmid, Frank and Poljansky, Stefan and Haen, Ekkehard and Hajak, Goeran (2004) Genetic tau-variants in patients with frontotemporal dementia. PSYCHIATRISCHE PRAXIS, 31. S55-S57. ISSN 0303-4259,
Full text not available from this repository. (Request a copy)Abstract
Objevctive: To evaluate tau-associated genetic polymorphisms in patients with sporadic frontotemporal dementia (FTD) and healthy control subjects. Method: Tau-gene sequence of 30 patients with FTD and 30 healthy controls was analysed by polymerase-chain-reaction (PCR). Subsequent sequencing was performed to identify exonic and intronic differences between both groups. Results: The following polypmorphisms, which are localized closely to each exon-intron-border, have been identified: In 37% (n = 11) of the control subjects three different intronic polymorphisms occur simultaneously (Intron 2, 263, C --> Y; Intron 3, 590, A --> R; Intron 11,150, G --> A). In the FTD group, this coexistance has been observed only in 17% (n = 5). Conclusions: In how far there exists a significant correlation between the newly identified triple polymorphism in the Tau gene and an alternated risk for FTD must be evaluated in a lager population. The proximity of these polymorphisms to the exon-intron border would facilitate functional influences on gene expression patterns. These preliminary results described, above potentially point to further pathogenetic factors in the genesis of FTD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOBAR DEGENERATION; DISEASE; SEVERITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jun 2021 09:46 |
| Last Modified: | 25 Jun 2021 09:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37028 |
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