Wodarz, Norbert and Lange, Kirsten and Laufkoetter, Rainer and Johann, Monika (2004) ADHD and alcohol dependence: A common genetic predisposition? PSYCHIATRISCHE PRAXIS, 31. S111-S113. ISSN 0303-4259,
Full text not available from this repository. (Request a copy)Abstract
Introduction: Nearly 50% of subjects with continuing symptoms of attention-deficit hyperactivity disorder (ADHD) in adulthood show a comorbid substance use disorder. Both, ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability. Method: We investigated phenotype and 5-HTT/5-HT2c allelic characteristics in 314 alcoholics of German descent. Result: 21 % of the alcoholics fulfilled DSM-IV-criteria of ADHD with ongoing symptoms in adulthood. There was no significant difference in 5-HTT- or 5-HT2c-allele distribution between alcoholics and matched controls or between alcoholics with or without ADHD. Conclusion: In our sample the functional relevant 5-HTT-promoter and the 5-HT2c-receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEFICIT HYPERACTIVITY DISORDER; PROMOTER REGION POLYMORPHISM; SEROTONIN TRANSPORTER GENE; PROLACTIN RESPONSE; FENFLURAMINE; PERSONALITY; ASSOCIATION; 5-HTTLPR; RECEPTOR; ABUSE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jun 2021 10:40 |
| Last Modified: | 25 Jun 2021 10:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37048 |
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