Steiling, Heike and Muehlbauer, Marcus and Bataille, Frauke and Schoelmerich, Juergen and Werner, Sabine and Hellerbrand, Claus (2004) Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease. AMERICAN JOURNAL OF PATHOLOGY, 165 (4). pp. 1233-1241. ISSN 0002-9440, 1525-2191
Full text not available from this repository. (Request a copy)Abstract
Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family, is a specific mitogen for different types of epithelial cells and a potent survival factor for these cells under stress conditions. KGF expression increases strongly after injury to various tissues, including the skin and the intestine, and signaling via the KGF receptor was shown to be crucial for repair of skin wounds and for liver regeneration. Here we demonstrate an increased expression of KGF in chronic liver disease associated with fibrosis. The extent of KGF overexpression correlated strongly with the stage of fibrosis. As the cellular source of KGF we identified activated hepatic stellate cells (HSCs)/myofibroblasts. in contrast to the ligand, the KGF receptor, FGFR2-IIIb, was exclusively expressed by hepatocytes, but not by activated HSCs or other parenchymal or nonparenchymal liver cells. Based on the known effects of KGF on hepatocytes in vitro, our findings suggest that HSC/myofibroblast-derived KGF may enhance liver regeneration and/or hepatocyte survival in patients with chronic liver disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; DELTA T-CELLS; FACTOR RECEPTOR; IN-VITRO; DIFFERENTIAL EXPRESSION; HUMAN HEPATOCYTES; EPITHELIAL-CELLS; CARCINOMA-CELLS; GENE-TRANSFER; KGF RECEPTOR; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 05:26 |
| Last Modified: | 28 Jun 2021 05:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37092 |
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