Wyen, Christoph and Hoffmann, Christian and Schmeier, Norbert and Woehrmann, Andrej and Qurishi, Nazifa and Rockstroh, Juergen and Esser, Stefan and Rieke, Ansgar and Ross, Birgit and Lorenzen, Thore and Schmitz, Karina and Stenzel, Werner and Salzberger, Bernd and Fätkenheuer, Gerd (2004) Progressive multifocal leukencephalopathy in patients on highly active antiretroviral therapy - Survival and risk factors of death. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 37 (2). pp. 1263-1268. ISSN 1525-4135,
Full text not available from this repository. (Request a copy)Abstract
Objective: To describe the clinical course and risk factors of death in highly active antiretroviral therapy (HAART)-treated patients with progressive multifocal leukencephalopathy (PML); to evaluate the efficacy of cidofovir in addition to HAART. Methods: Retrospective multicenter cohort study of PML in HIV-1-infected patients. Diagnosis of PML was confirmed by histology by positive polymerase chain reaction for JC virus (JCV) in cerebrospinal fluid (CSF) or was made by typical radiologic and clinical findings. Results: Thirty-five cases of PML were identified. The diagnosis was made by histology (9 cases), detection of JCV in CSF (17 cases), and by radiologic findings (9 cases). Upon manifestation of PML, 15135 patients had never received HAART, and 11135 were on HAART for >6 months (median 1126 days). In 9/35 cases, clinical manifestation of PML occurred within 6 months after initiation of HAART. All patients received HAART after PML diagnosis. Aftera median follow-up of 553 days (range 28-2694 days), the median survival time was not reached. In 12 patients who were treated concomitantly with cidofovir, cumulative survival was significantly shorter than in patients without cidofovir (P = 0.03). Patients in whom PML was diagnosed while on HAART demonstrated a trend toward a shorter survival than HAART-naive patients (P = 0.15). Conclusions: PML continues to occur in HIV-1-infected patients even when they are treated with HAART. Patients developing PML on HAART had a trend toward a shorter median Survival compared with treatment-naive patients, and cidofovir therapy was not associated with improved survival in this cohort.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE RECONSTITUTION; LEUKOENCEPHALOPATHY; AIDS; ERA; HAART; PROGNOSIS; CIDOFOVIR; IMPROVES; EPIDEMIOLOGY; progressive multifocal leukencephalopathy; cidofovir; highly active antiretroviral therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 08:45 |
| Last Modified: | 28 Jun 2021 08:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37129 |
Actions (login required)
 |
View Item |
