Nave, Heike and Bedoui, Sammy and Moenter, Frank and Steffens, Jan and Felies, Melanie and Gebhardt, Thomas and Straub, Rainer H. and Pabst, Reinhard and Dimitrijevic, Mira and Stanojevic, Stanislava and von Hoersten, Stephan (2004) Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y-2 receptor activation. JOURNAL OF NEUROIMMUNOLOGY, 155 (1-2). pp. 1-12. ISSN 0165-5728, 1872-8421
Full text not available from this repository. (Request a copy)Abstract
Neuropeptide Y (NPY) increases survival in experimental septic shock, which might be mediated by cardiovascular and/or immunological effects. To study the latter hypothesis, we monitored blood leukocyte subsets over 96 h after intravenous (i.v.) application of LPS in chronically i.v.-cannulated rats. LPS induced a dramatic leukopenia at 4 h after challenge, which was blunted in NPY-treated animals by stabilizing granulocyte and T-lymphocyte numbers. In addition, NPY treatment prevented tissue immigration of monocytes at early time points and consecutively mobilized activated monocytes from the third day after challenge. RT-PCR and in vitro adhesion studies provided evidence for a NPY Y-2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. (C) 2004 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VIVO; LEUKOCYTE MOBILIZATION; PEPTIDE YY; RAT; NPY; NEUROTRANSMITTERS; INHIBITION; SECRETION; IMMUNITY; SUBSETS; monocytes/macrophages; rodent; endotoxic shock; cell trafficking; lung |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 09:42 |
| Last Modified: | 28 Jun 2021 09:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37138 |
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