Blesch, A. and Yang, H. and Weidner, Norbert and Hoang, A. and Otero, D. (2004) Axonal responses to cellularly delivered NT=4/5 after spinal cord injury. MOLECULAR AND CELLULAR NEUROSCIENCE, 27 (2). pp. 190-201. ISSN 1044-7431,
Full text not available from this repository. (Request a copy)Abstract
Neurotrophic factors delivered to the injured spinal cord have been shown to enhance axonal growth, prevent neuronal degeneration and partially improve sensorimotor function. The present study examined the effects of NT-4/5 on growth of spinal and supraspinal axons, glia, and functional outcome after spinal cord injury. Adult Fischer 344 rats received spinal cord dorsal hemisections or complete transections at the midthoracic level. Fibroblasts modified to secrete NT-4/5 or green fluorescent protein as controls were immediately grafted to the lesion site. Axonal growth responses were determined between 3 and 6 months postinjury by retrograde and anterograde tracing and immunohistochemistry. Motor axons, coerulospinal, reticulospinal, and propriospinal axons responded to NT-4/5 delivery after thoracic spinal cord injury with significantly increased axonal penetration into NT-4/5 secreting grafts compared to C.FP-expressing control grafts. Axonal growth beyond NT-4/5-producing grafts and functional recovery were not observed. Numerous Schwann cells, but not oligodendrocytes, were present within NT-4/5-secreting grafts and remyelinated axons inside the graft. Thus, NT-4/5 and BDNF appear to be interchangeable to elicit substantial axonal growth in the injured spinal cord. (C) 2004 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NERVE GROWTH-FACTOR; NEURONS IN-VIVO; ADULT-RAT; CORTICOSPINAL NEURONS; NEUROTROPHIC FACTOR; GENE-THERAPY; BDNF; RECOVERY; TRKB; NT-3; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 07:05 |
| Last Modified: | 28 Jun 2021 07:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37149 |
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