Peng, X. and Kessler, Alexandra and Phan, H. and Garrett, R. A. and Prangishvili, David (2004) Multiple variants of the archaeal DNA rudivirus SIRV1 in a single host and a novel mechanism of genomic variation. MOLECULAR MICROBIOLOGY, 54 (2). pp. 366-375. ISSN 0950-382X, 1365-2958
Full text not available from this repository. (Request a copy)Abstract
The DNA rudivirus SIRV1 of the hyperthermophilic archaeon Sulfolobus shows exceptional properties. Viral isolates invariably contain a population of variants with different but closely related genomes. Upon propagation in a given host strain, one or more genomes dominate in the viral population. However, upon passage into a new host strain the viral population undergoes changes and other dominant variants are selected. Sequencing and analysis of the variant genomes revealed that major differences occur in gene order, gene size and gene content at localized genomic sites. A previously unknown mechanism of genomic rearrangement involving putative 12 bp archaeal introns appears to facilitate alteration of the variant genomes. Inter-genomic recombination between the different variants also occurs. The variant genomes exhibit signature tetranucleotide sequences near their putative sites for replication initiation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMOPHILIC ARCHAEA; EUKARYAL VIRUSES; SULFOLOBUS; LIPOTHRIXVIRUS; DIVERSE; INTRONS; FAMILY; SIFV; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie (Archaeenzentrum) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 07:10 |
| Last Modified: | 28 Jun 2021 07:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37150 |
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