Busch, Volker and Frese, A. and Bartsch, T. (2004) The trigemino-cervical complex. Integration of peripheral and central pain mechanisms in primary headache syndromes. SCHMERZ, 18 (5). 404-+. ISSN 0932-433X, 1432-2129
Full text not available from this repository. (Request a copy)Abstract
The activation of the trigeminal nociceptive system is the neural substrate of pain in primary headache syndromes such as migraine and cluster headache. The nociceptive inflow from the meninges to the spinal cord is relayed in brainstem neurones of the trigemino-cervical complex (TCC). Two important mechanisms of pain transmission are reviewed: convergence of nociceptive trigeminal and cervical afferents and sensitization of trigemino-cervical neurones. These mechanisms have clinical correlates such as hyperalgesia, allodynia, spread and referral of pain to trigeminal or cervical dermatomes. Neurones in the TCC are subject to a modulation of pain-modulatory circuits in the brainstem such as the periaqueductal grey (PAG). Recent experimental and clinical findings of a modulation of these pain processes are discussed. The review focuses on TCC neurones as integrative relay neurones between peripheral and central pain mechanisms. The understanding of these mechanisms has implications for the understanding of the clinical phenomenology in primary headache syndromes and the development of therapeutical options.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ELECTRICAL NERVE-STIMULATION; GAMMA-AMINOBUTYRIC-ACID; GREATER OCCIPITAL NERVE; SPINAL-CORD STIMULATION; NOCICEPTIVE NEURONS; PERIAQUEDUCTAL GRAY; DORSAL HORN; DURA-MATER; INPUT; MIGRAINE; trigemino-cervical complex; migraine; pain modulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 08:41 |
| Last Modified: | 28 Jun 2021 08:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37171 |
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