May, Florian and Weidner, N. and Matiasek, K. and Vroemen, M. and Mrva, T. and Caspers, C. and Henke, J. and Brill, T. and Lehmer, A. and Blesch, A. and Erhardt, W. and Gaensbacher, B. and Hartung, R. (2004) Experimental therapeutic strategies for cavernous nerve lesions: nerve guides, tissue engineering, and gene therapy. UROLOGE A, 43 (10). pp. 1242-1248. ISSN 0340-2592,
Full text not available from this repository. (Request a copy)Abstract
Dissection of the cavernous nerves eliminates spontaneous erections and may lead to irreversible erectile dysfunction due to degeneration of cavernous tissue. Novel procedures to reconstruct penile innervation include cavernous nerve interposition grafting and neurotrophic treatments to revitalize penile neural input, evaluated thus far in various preclinical models of cavernous nerve injury. Schwann cells crucially contribute to successful axonal regeneration by mechanical and paracrine mechanisms in the injured nerve, and Schwann cells seeded into guidance channels have been successfully employed to support regeneration in animal models of cavernous nerve injury. Gene therapy, tissue engineering, and reconstructive techniques have been combined to deliver neurotrophic factors and recover erectile function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESTORE ERECTILE FUNCTION; ENDOTHELIAL GROWTH-FACTOR; PERIPHERAL-NERVE; NEUROTROPHIC FACTOR; SCHWANN-CELLS; RAT MODEL; REGENERATION; INJURY; RECOVERY; ABLATION; Schwann cells; nerve regeneration; erection; cavernous nerves; neurotrophic factors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 10:25 |
| Last Modified: | 28 Jun 2021 10:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37177 |
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