Handel, Martin and Phillips, Oliver and Anders, Sven and Koeck, Franz Xaver and Sell, Stefan (2004) Dose-dependent efficacy of diclofenac-cholestyramine on pain and periarticular ossifications after total hip arthroplasty: a double-blind, prospective, randomised trial. ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 124 (7). pp. 483-485. ISSN 0936-8051,
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Introduction: To investigate the efficacy of treatment with diclofenac-cholestyramine on postoperative pain and functional outcome after total hip arthroplasty, a randomised double-blind study was conducted. Materials and methods: A total of 245 patients received postoperative treatment with 75 mg or 150 mg diclofenac p.o. daily for 14 days. Results: Patients who received 75 mg diclofenac per day needed paracetamol as an additional analgesic significantly more often (p=0.0162) than patients who were treated with 150 mg diclofenac daily (75 mg twice a day). The incidence of adverse gastrointestinal events was significantly lower in the group receiving 75 mg diclofenac daily than in the group receiving the higher dose (23.1% vs 37.1%; p=0.025). Six months after the operation, no differences were observed between the two groups with regard to pain or functionality measured in terms of overall mobility of the hip. No patient of either group developed clinically relevant heterotopic ossifications. Conclusion: Treatment with a dose of 75 mg diclofenac once daily-if necessary with the additional use of paracetamol-is a favourable option for the postoperative care of THA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HETEROTOPIC OSSIFICATION; ECTOPIC OSSIFICATION; PROPHYLAXIS; REPLACEMENT; PREVENTION; heterotopic ossification; diclofenac; total hip arthroplasty |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jun 2021 12:46 |
| Last Modified: | 28 Jun 2021 12:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37205 |
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