Landgraf, Rainer and Neumann, Inga D. (2004) Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. FRONTIERS IN NEUROENDOCRINOLOGY, 25 (3-4). pp. 150-176. ISSN 0091-3022, 1095-6808
Full text not available from this repository. (Request a copy)Abstract
As exemplified particularly with vasopressin and oxytocin, release of neuropeptides within the brain occurs from dendrites, somata, and axons of neurosecretory neurons; mechanisms include activation of intracellular Ca2+ stores, changed strength of synaptic input and altered interaction between transcription factors and gene promoters. Upon demand, both diffuse spread of neuropeptides in the extracellular fluid following dendritic release and focal release from axonal terminals may contribute to regionally and temporally varying combinations of neuromodulator and neuro transmitter actions, thus providing a theoretically unlimited variability in interneuronal signaling. Thus, instead of favoring volume or synaptic transmission following central neuropeptide release, a more dynamic concept is presented with multiple and variable modes of release and communication. This concept considers neuropeptides in the extracellular fluid of the brain rather than those in the cerebrospinal fluid or plasma as primary signals, triggering a variety of receptor-mediated effects, including those underlying behavioral and neuroendocrine regulation and psychopathology. (C) 2004 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAT SUPRAOPTIC NUCLEUS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ANXIETY-RELATED BEHAVIOR; PITUITARY-ADRENAL AXIS; CENTRAL-NERVOUS-SYSTEM; PUSH-PULL PERFUSION; MAGNOCELLULAR NEUROSECRETORY NEURONS; NEUROENDOCRINE STRESS RESPONSES; SOCIAL RECOGNITION RESPONSES; HUMAN CEREBROSPINAL-FLUID; dendritic release; CRF; anxiety; HAB; CSF; blood-brain barrier; microdialysis; social behavior |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 Jan 2022 10:54 |
| Last Modified: | 18 Jan 2022 10:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37235 |
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