Voelker, Michael and Shinoda, Kei and Sachs, Helmut and Gmeiner, Helmut and Schwarz, Thorsten and Kohler, Konrad and Inhoffen, Werner and Bartz-Schmidt, Karl Ulrich and Zrenner, Eberhart and Gekeler, Florian (2004) In vivo assessment of subretinally implanted microphotodiode arrays in cats by optical coherence tomography and fluorescein angiography. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 242 (9). pp. 792-799. ISSN 0721-832X, 1435-702X
Full text not available from this repository. (Request a copy)Abstract
Background: Following multiple promising investigations into restoration of vision in degenerative retinal disease by implantation of a sub- or epiretinal prosthesis, the step to clinical use in humans is impending. In this study we intended to establish optical coherence tomography (OCT) and fluorescein angiography (FA) first in research animals for noninvasive assessment of the condition of the posterior pole of eyes after intraocular implant surgery. Methods: Three adult cats that had undergone subretinal implant surgery were evaluated by OCT and FA between 1 and 470 days postoperatively. Eight adult cats served as control. In addition histology was performed. Results: In all three cats OCT demonstrated stable positioning of the implants in the subretinal space during the complete examination period. Transient retinal edema was found in the early postoperative period but decreased during follow-up. The retina over the implants was well attached at all times in cats 1 and 2; however, in cat 3 localized retinal detachment was demonstrated. FA showed intact retinal vasculature over the subretinal implant in high detail without interference from choroidal background fluorescence. Conclusions: OCT and FA have been fruitfully applied to cats to assess the morphological and circulatory conditions of the neuroretina and of its interface with the subretinal implant. The techniques may therefore provide a tool for objective, noninvasive in vivo evaluation of eyes that have undergone subretinal implant surgery, both in research animals and in humans.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REPLACE DEGENERATED PHOTORECEPTORS; RETINITIS-PIGMENTOSA; ELECTRICAL-STIMULATION; MORPHOMETRIC-ANALYSIS; RETINAL IMPLANTS; RABBIT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jun 2021 06:07 |
| Last Modified: | 30 Jun 2021 06:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37238 |
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