Klopocki, Eva and Kristiansen, Glen and Wild, Peter J. and Klaman, Irina and Castanos-Velez, Esmeralda and Singer, Gad and Stohr, Robert and Simon, Ronald and Sauter, Guido and Leibiger, Haike and Essers, Lutz and Weber, Birgit and Hermann, Klaus and Rosenthal, Andre and Hartmann, Arndt and Dahl, Edgar (2004) Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. INTERNATIONAL JOURNAL OF ONCOLOGY, 25 (3). pp. 641-649. ISSN 1019-6439, 1791-2423
Full text not available from this repository. (Request a copy)Abstract
Aberrant activation of the Wnt signaling, pathway plays an important role in the development of solid tumors such as breast and colon cancer. Secreted Frizzled-related protein I (SFRP1) is a negative regulator of the Wnt pathway. It has been described that SFRP1 mRNA is strongly down-regulated in breast cancer and a putative tumor suppressor function has been postulated. We have generated and characterized an SFRP1 specific antibody to analyze its expression on protein level and to investigate the association of SFRP1 expression with clinicopathological parameters and patient survival. Analysis of >2000 invasive breast tumors and 56 carcinoma in situ revealed similar frequencies of SFRP1 loss in these tumors (46% and 43% respectively). Therefore, we propose that loss of SFRPI expression is an early event in breast tumorigenesis. SFRPI expression was inversely correlated with tumor stage (p<0.001) but not with tumor grade (p=0.14) or lymph node status (p=0.84). Performing a multivariate analysis we could confirm the association between tumor stage and SFRPI expression (p=0.029). In particular, loss of SFRPI expression in early stage breast tumors (pT1) was associated with poor prognosis (p=0.04). In conclusion, expression of SFRPI is commonly lost in breast cancer. SFRPI expression might be useful as a novel prognostic marker in early stage breast cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FRIZZLED-RELATED PROTEIN; HUMAN COLORECTAL-CANCER; TISSUE MICROARRAYS; BETA-CATENIN; EXPRESSION; GENES; IDENTIFICATION; TUMORIGENESIS; INHIBITION; APOPTOSIS; breast cancer; tumor suppressor gene; tissue microarray; prognostic marker; Wnt pathway |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jun 2021 07:45 |
| Last Modified: | 30 Jun 2021 07:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37261 |
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