Morawietz, L. and Gehrke, T. and Classen, R. A. and Barden, B. and Otto, M. and Hansen, T. and Aigner, T. and Stiehl, P. and Neidel, J. and Schroeder, J. H. and Frommelt, L. and Schubert, Thomas and Meyer-Scholten, C and Koenig, A. and Stroebel, P. and Rader, C. P. and Kirschner, S. and Lintner, F. and Ruether, W. and Skwara, A. and Bos, I. and Kriegsmann, J. and Krenn, V. (2004) Proposal for the classification of the periprosthetic membrane from loosened hip and knee endoprostheses. PATHOLOGE, 25 (5). pp. 375-383. ISSN 0172-8113, 1432-1963
Full text not available from this repository. (Request a copy)Abstract
After 10 years, loosening of total joint endoprostheses occurs in about 3 to 10 percent of all patients, requiring elaborate revision surgery. A periprosthetic membrane is routinely found between bone and loosened prosthesis. Further histomorphological examination allows determination of the etiology of the loosening process. Aim of this study is the introduction of clearly defined histopathological criteria for a standardized evaluation of the periprosthetic membrane. Based on histomorphological criteria and polarized light microscopy, four types of the periprosthetic membrane were defined: periprosthetic membrane of wear particle type (type I), periprosthetic membrane of infectious type (type II), periprosthetic membrane of combined type (type III), periprosthetic membrane of indifferent type (type IV). Periprosthetic membranes of 268 patients were analyzed according to the defined criteria. The correlation between histopathological and microbiological diagnosis was high (89%, p<0,001), the inter-observer reproducibility was sufficient (95%). This classification system enables a standardized diagnostic procedure and therefore is a basis for further studies concerning the etiology of and pathogenesis of prosthesis loosening.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLYETHYLENE WEAR DEBRIS; SMALL-COLONY VARIANTS; STAPHYLOCOCCUS-AUREUS; IMPLANT INTERFACE; RAT MODEL; FOLLOW-UP; ARTHROPLASTY; PROSTHESIS; BONE; REPLACEMENTS; endoprosthesis loosening; aseptic loosening; septic loosening; classification; histopathology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jun 2021 07:08 |
| Last Modified: | 29 Jun 2021 07:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37292 |
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