Haring, Robin and Wallaschofski, Henri and Voelzke, Henry and Flessa, Steffen and Keevil, Brian G. and Nauck, Matthias and Baumeister, Sebastian E. (2016) Associations of androgens with health care utilization and costs in women-Perspectives of a population-based cohort study. MATURITAS, 89. pp. 5-8. ISSN 0378-5122, 1873-4111
Full text not available from this repository. (Request a copy)Abstract
Objective: Despite associations between total testosterone (TT) concentrations and increased cardiometabolic risk, the impact of serum androgens on health care utilization and costs among women is unknown. Methods: We used data from 1521 women in the population-based cohort Study of Health in Pomerania (SHIP) to investigate the associations of serum TT (measured by liquid chromatography-tandem mass spectrometry), sex hormone-binding globulin (SHBG), and free testosterone (free T) with health care utilization and costs at baseline and five-year follow-up (N = 1210), implementing multivariable-adjusted econometric models. Results: Cross-sectional analyses showed no association of TT, SHBG, or free T with hospitalization or total health costs (outpatient as well as inpatient costs). Prospective analyses revealed an inverse association of baseline SHBG with follow-up total health care costs (% change per standard deviation (SD): -26.2%, 95% confidence interval (CI): -42.2%; -8.9%) and inpatient costs (% change per SD: -26.5%%, 95% CI: -45.5%; 2.5%). Baseline free T was positively associated with total health care costs at the five-year follow-up (% change per SD: +37.7%, 95% CI: + 4.6%; + 81.4%). Conclusions: In this first cost analysis among women from the general population, we observed no association of androgen serum concentration with health care utilization and costs. However, baseline SHBG appeared to be inversely correlated and free T positively correlated with long-term health care costs. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSTMENOPAUSAL WOMEN; ENDOGENOUS ESTROGEN; ECONOMIC-EVALUATION; TESTOSTERONE; RISK; SERUM; METAANALYSIS; SHBG; Total testosterone; Androgens; Sex hormones; Women; Health care utilization; Costs |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2019 13:55 |
| Last Modified: | 09 Apr 2019 13:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3736 |
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