Putzhammer, Albert and Heindl, Bernhard and Broll, Karin and Pfeiff, Liane and Perfahl, Maria and Hajak, Goeran (2004) Spatial and temporal parameters of gait disturbances in schizophrenic patients. SCHIZOPHRENIA RESEARCH, 69 (2-3). pp. 159-166. ISSN 0920-9964,
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This study assessed the locomotor patterns of gait in schizophrenic patients and differentiated intrinsic effects of the illness from those caused by conventional and atypical neuroleptic treatment. Gait parameters of drug-naive, conventionally and atypically treated patients as well as control subjects were evaluated. Differences in gait velocity and in stride length between the four investigated groups were highly significant (ANOVA: p<0.001). Mean gait velocities of all patient groups were significantly slower than-those of controls, with the most striking difference observed between the control group and patients treated with conventional neuroleptics (p<0.001). Amongst the patient groups, significant differences were detected between patients treated with conventional neuroleptics and both patients treated with atypical neuroleptics and drug-naive patients (p<0.05), but not between untreated and atypically treated patients. In all patient groups the reduction of gait velocity was due to a smaller mean stride length, while the cadence (steps per minute) was not changed. These results indicate that schizophrenia causes a primary disturbance of stride length regulation. Conventional antipsychotic treatment intensifies this deficit, whereas atypical antipsychotic treatment does not cause any additional gait disturbances. In contrast to the spatial parameters, the temporal structure of schizophrenic gait is not affected either by antipsychotic treatment or schizophrenia itself (C) 2003 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LUMBAR SPINE KINEMATICS; NEUROLOGICAL SOFT SIGNS; MONKEY GLOBUS-PALLIDUS; PARKINSONS-DISEASE; SENSORIMOTOR CORTEX; NEUROLEPTIC-NAIVE; VOLUNTARY MOVEMENT; MOTOR STIMULATION; HEALTHY CONTROLS; ACTIVATION; schizophrenia; movement; gait; hypokinesia; parkinsonism; antipsychotic agents |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2021 14:14 |
| Last Modified: | 06 Jul 2021 14:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37416 |
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