Bartsch, Detlef K. and Kress, Ralf and Sina-Frey, Mercedes and Gruetzmann, Robert and Gerdes, Berthold and Pilarsky, Christian and Heise, Joachim W. and Schulte, Klaus-Martin and Colombo-Benkmann, Mario and Schleicher, Cristina and Witzigmann, Helmut and Pridoehl, Olaf and Ghadimi, Michael B. and Horstmann, Olaf and von Bernstorff, Wolfgang and Jochimsen, Lisa and Schmidt, Jan and Eisold, Sven and Estevez-Schwarz, Lope and Hahn, Stephan A. and Schulmann, Karsten and Boecker, Wolfgang and Gress, Thomas M. and Zuegel, Nikolaus and Breitschaft, Karl and Prenzel, Klaus and Messmann, Helmut and Endlicher, Esther and Schneider, Margarete and Ziegler, Andreas and Schmiegel, Wolff and Schaefer, Helmut and Rothmund, Matthias and Rieder, Harald (2004) Prevalence of familial pancreatic cancer in Germany. INTERNATIONAL JOURNAL OF CANCER, 110 (6). pp. 902-906. ISSN 0020-7136,
Full text not available from this repository. (Request a copy)Abstract
Based on several case-control studies, it has been estimated that familial aggregation and genetic susceptibility play a role in up to 10% of patients with pancreatic cancer, although conclusive epidemiologic data are still lacking. Therefore, we evaluated the prevalence of familial pancreatic cancer and differences to its sporadic form in a. prospective multicenter trial. A total of 479 consecutive patients with newly diagnosed, histologically confirmed adenocarcinoma of the pancreas were prospectively evaluated regarding medical and family history, treatment and pathology of the tumour. A family history for pancreatic cancer was confirmed whenever possible by reviewing the tumour specimens and medical reports. Statistical analysis was performed by calculating odds ratios, regression analysis with a logit-model and the Kaplan-Meier method. Twenty-three of 479 (prevalence 4.8%, 95% CI 3.1-7.1) patients reported at least 1 first-degree relative with pancreatic cancer. The familial aggregation could be confirmed by histology in 5 of 23 patients (1.1%, 95% CI 0.3-2.4), by medical records in 9 of 23 patients (1.9%, 95% CI 0.9-33) and by standardized interviews of first-degree relatives in 17 of 23 patients (33%, 95% CI 2.1-5.6), respectively. There were no statistical significant differences between familial and sporadic pancreatic cancer cases regarding sex ratio, age of onset, presence of diabetes mellitus and pancreatitis, tumour histology and stage, prognosis after palliative or curative treatment as well as associated tumours in index patients and families, respectively. The prevalence of familial pancreatic cancer in Germany is at most 3.5% (range 1.1-3.5%) depending on the mode of confirmation of the pancreatic carcinoma in relatives. This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer. (C) 2004 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RISK-FACTORS; GERMLINE MUTATIONS; DIABETES-MELLITUS; CIGARETTE-SMOKING; GENE-MUTATIONS; HISTORY; CARCINOMA; BRCA2; ADENOCARCINOMA; AGGREGATION; familial pancreatic cancer; prevalence; epidemiology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2021 05:13 |
| Last Modified: | 07 Jul 2021 05:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37428 |
Actions (login required)
 |
View Item |
